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KMID : 0374920050260010067
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Inje Medical Journal
2005 Volume.26 No. 1 p.67 ~ p.74
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An Effect of Propofol and Ondansetron as Prophylaxis against Postoperative Nausea and Vomitig in Children Undergoing Tonsillectomy
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Kim Young-Jae
Lee Kun-Moo
Lee Jeong-Han
Cheong Soon-Ho
Choe Young-Kyun
Shin Chee-Mahn
Ku Bong-Geun
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Abstract
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Objective: To examine the prophylactic effect of ondansetron and propofol against postoperative nausea and vomiting(PONV) in children undergoing tonsill ectomy
Methods and Materials: Sixty children(aged 3-11 years) who underwent tonsillectomy received antiemetics (ondansetron group; ondansetron 0.1mg/kg, propofol group; propofol 0.5mg/kg) or not (control group) at the end of surgery. Anesthesia was induced with ketamine(1mg/kgiv) and rocuronium(0.5mg/kg) and maintained by inhalation anesthesia with 2-3vol% sevoflurane in 50% N_(2)O/O_(2). Premedication was given as atropine 0.01mg/kg iv. Ketorolac(1mg/kg) was injected for postoperative analgesia immediate after induction. They were monitored the incidence of PONV at operation room, postanesthetic care unit(PACU) and admission room.
Results: No significant differences were observed in the total incidence of PONV among the groups. But ondansetron and propofol group made a difference(p<0.05) in the incidence of PONV at operation room compared with control group.
Conclusion: In children undergoing tonsillectomy, ondansetron(0.1mg/kg) and propofol(0.5mg/kg) may have a prophylactic effect against PONV at operation room.
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KEYWORD
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Postoperative nausea and vomitig, Children, Tonsillectomy, Ondansetron, Propofol
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